ML 141

Product Name: ML 141
CAS No.: 71203-35-5
Chemical Name: ML 141
Synonyms: ML 141;CS-1743;CID-2950007;ML141;ML 141;ML 141 USP/EP/BP;ML141(CID-2950007);ML141;ML 141;CID-2950007;Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem;5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline;4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
CBNumber: CB72538281
Molecular Formula: C22H21N3O3S
Formula Weight: 407.49
MOL File: 71203-35-5.mol

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ML 141 Property

Melting point:: 216 °C(Solv: ethanol (64-17-5))
Boiling point:: 622.9±65.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL (warmed, clear solution)
form: Yellow-white solid
pka: 10.39±0.10(Predicted)
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0407
Product name: ML 141
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $127
Updated: 2024/03/01

Sigma-Aldrich

Product number: 217708
Product name: Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
Packaging: 25mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 18496
Product name: ML 141
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18496
Product name: ML 141
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0407
Product name: ML 141
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $505
Updated: 2024/03/01

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ML 141 Chemical Properties,Usage,Production

Uses

ML 141 has been used:

to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells

Definition

ChEBI: 4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide is a sulfonamide.

Biochem/physiol Actions

ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.

storage

Store at +4°C

ML 141 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML 141 Suppliers

China 79 India 1 United Kingdom 2 United States 16 Global 98

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

71203-35-5, ML 141Related Search:

9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl- Nodinitib-1 ML385 ML365 ML355 M348 ml390 (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML277 ML364 VU0456810 ML-327 IKK 16 Pictilisib NSC 23766 (hydrochloride) Entinostat EHT1864

4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)benzenesulfonamide

CID-2950007

4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide ML141

4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide

ML 141

5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline

ML141;ML 141

4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide

4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

CS-1743

ML141(CID-2950007)

ML141;ML 141;CID-2950007

Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem

4-[2-(1-PIPERIDINYL)ETHYL]-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZI<WBR />NE TRIHYDROCHLORIDE

Benzenesulfonamide, 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-

ML 141 USP/EP/BP

71203-35-5

Inhibitors

API